![]() You can live for years with a friendly worm and show no negative symptoms. They’re skilled at establishing themselves in the body without harming their host.They’re the most successful organisms to infect humans – dating back as far as archaic humans.So what makes them of such interest to the scientists who study them? Why study worms?Īs long as there have been humans, there have been human parasites – opportunistic hitchhikers that seek resource and refuge inside our bodies. Similar trials for perennial allergic rhinitis (hayfever) and eosinophilic esophagitis – a chronic, allergic inflammatory disease of the oesophagus – are in development.Īs part of this research, the Institute has also been developing techniques for sorting, harvesting and storing hookworm, to ultimately establish a safe, reliable and consistent GMP (good manufacturing practice) grade hookworm product that can be used safely for ongoing trials and ultimately in some form as an approved therapeutic product. ![]() This research was extended in September 2020 to investigate the feasibility of using human hookworms as a medication-free maintenance therapy for ulcerative colitis, an inflammatory bowel disease. The study seeks to understand the effects human hookworms have on a healthy individual’s immune system, gut bacteria composition and function. In 2019, the Malaghan Institute began a clinical study to explore the therapeutic potential of human hookworms. ![]()
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